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ResourcesResearch IntegrityTwo in 100 clinical trials in eight major journals likely contain inaccurate data: Study – Retraction Watch (Ivan Oransky | June 2017)

Australasian Human Research Ethics Consultancy Services Pty Ltd (AHRECS)

Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study – Retraction Watch (Ivan Oransky | June 2017)

 


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A sweeping analysis of more than 5,000 papers in eight leading medical journals has found compelling evidence of suspect data in roughly 2% of randomized controlled clinical trials in those journals.

This is not the first time such an observation has been made and it probably won’t be the last. Distorted evidence is a cause for concern when it leads to poor (or even dangerous decision making), but we’re left wondering if we need to try to gather such observations into an omnibus and footnoted a single item in the Resource Library. What do you think? Drop us a line (gary.allen@ahrecs.com) and let us know what you think. This report does highlight the importance for clinical decision making of being well-read on a topic rather than relying on a small sample of articles supporting a treatment.

Although the analysis, by John Carlisle, an anesthetist in the United Kingdom, could not determine whether the concerning data were tainted by misconduct or sloppiness, it suggests that editors of the journals have some investigating to do. Of the 98 studies identified by the method, only 16 have already been retracted. [See update at end.] .
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The types of studies analyzed — randomized controlled clinical trials — are considered the gold standard of medical evidence, and tend to be the basis for drug approvals and changes in clinical practice. Carlisle, according to an 
editorial by John Loadsman and Tim McCulloch accompanying the new study published today in Anesthesia,

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