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ResourcesHuman Research EthicsHow about personally optimized treatment? – The Ethics Blog (Pär Segerdahl | March 2019)

Australasian Human Research Ethics Consultancy Services Pty Ltd (AHRECS)

How about personally optimized treatment? – The Ethics Blog (Pär Segerdahl | March 2019)

Published/Released on March 06, 2019 | Posted by Admin on December 31, 2019 / , , , , , , ,
 


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It is well known that patients who are asked to participate in cancer trials are tempted by the therapeutic misconception. They believe they are offered a newer and better treatment, when in fact it is about research into an untested treatment. When researchers use genetic tests to develop personalized oncology, even more misconceptions can arise. I will soon explain. But first, what is personalized cancer treatment? Here is an example.

Patients whose tumor is to be operated may undergo preparatory radiation or chemotherapy. Since the preparatory therapy has severe side effects, one wants to avoid giving it to patients whose tumors do not respond to it. The challenge is to distinguish patients who respond to treatment from patients who do not. This is to be accomplished through, among other things, genetic tests on the tumor cells. If this works, you can develop personalized cancer treatment. Patients with the “right” tumor cell genetics receive the preparatory therapy, while patients who, according to the genetic tests, only get the side effects, with no effect on tumor growth, do not receive the therapy.

What are the misconceptions that can arise in patients who are asked to participate in research on personalized cancer treatment? Here are some examples.

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