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Animal Ethics Biosafety Human Research Ethics Research Integrity

Best practice methodology in the use of animals for scientific purposes 2017 (Updated July 2018), (NHMRC, et al | July 2018)

Posted by Dr Gary Allen in Animal Ethics on February 18, 2022
Keywords: Animal ethics, Animal Ethics Committee, Animal Research Ethics, Animal Welfare, Australia, Good practice

The Linked Original Item was Posted On July, 18 2018

A circular road sign with the words "Animal Welfare" against a sunny sky.

Aim of this document
This document is intended to support the implementation of the Code and the Code of Conduct by:

    • The Guidance is supported by the ARC, CSIRO and UA.

      In July 2018, the Guidance was updated to refer to the 2018 Australian Code for the Responsible Conduct of Research, and to include two references about the pre-registration of protocols for animal-based studies.

  • outlining best practice for the conduct of high quality animal-based studies
  • highlighting common flaws in methodologies employed in animal-based studies and issues that impact on their reproducibility
  • providing practical strategies for the implementation of best practice methodology, and to address issues related to reproducibility, during the planning, conduct, reporting and review of the use of animals for scientific purposes.

All activities outlined in this document must be conducted in accordance with relevant Commonwealth and state and territory legislation, and the Code.

The issues and recommendations in this document are outlined in broad rather than prescriptive or detailed terms. Key publications and resources providing detailed guidance and information are provided in accompanying references. Users should also be aware that the information in this document was current at the time of its publication, and that the practices they follow must accord with any changes in legislation and current best practice.

Contents
Acronyms

Key terms

Introduction

Regulatory framework
National standards and guidelines
Aim of this document
Scope
Structure
Intended audience

1. Framework for best practice methodology

1.1 The application of good scientific method
1.2 The application of Replacement, Reduction and Refinement (the 3Rs)
1.3 Effective and transparent reporting

2. Consequences of poor methodology

3. Major issues

3.1 Quality of experimental design
3.2 Quality of experimental statistics
3.3 Quality of techniques and procedures
3.4 Reporting

4. International guidance

5. Practical strategies

5.1 Institutions
5.2 Investigators
5.3 Animal ethics committees

6. References and resources

Additional publications and resources

Appendix 1: ARRIVE Guidelines Checklist

Appendix 2: PREPARE Guidelines Checklist

Appendix 3: Process report

Best practice methodology in the use of animals for scientific purposes | NHMRC
The ethical use of animals for scientific purposes is dependent on the quality of the studies; that is, how they are planned, designed, conducted, analysed and reported. High quality studies are essential to ensure the ethical use of animals, as well as the value and usefulness of the research.

Related Reading

ANZCCART Fact Sheets (September 2020)

Ethical guidelines for students in laboratory classes using animals or animal tissues – ANZCCART (December 2013)

(UK) NC3Rs – National Centre for the Replacement Refinement and Reduction of Animals in Research (Website)

(Nigeria) LAS around the globe: Animal care culture – from cultural and institutional norm, responsibility, and support standpoints (Papers: James O Fajemiroye | January 2022)

(UK) Animal researchers shoulder a psychological burden that animal ethics committees ought to address (Papers: Mike King & Hazem Zohny | March 2021)

(Europe) Ethical Review of Animal Research and the Standards of Procedural Justice: A European Perspective (Tomasz Pietrzykowski | July 2021)

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