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(Sweden) Transplant surgeon sentenced to prison for failed stem cell treatments – Science (Gretchen Vogel | June 2023)

Posted by Connar Allen in Human Research Ethics, Research Integrity on July 2, 2023
Keywords: Beneficence, Controversy/Scandal, International, Medical research

The Linked Original Item was Posted On July 21, 2023

Healthcare legislation and regulation, medical malpractice decision and health care injury personal attorney concept with gavel and stethoscope isolated on blue background

Paolo Macchiarini found guilty of gross assault against three patients on whom he tested synthetic tracheae

Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients today and sentenced to 2 years and 6 months in prison by an appeals court in Stockholm. The ruling comes a year after a Swedish district court found Macchiarini guilty of bodily harm in two of the cases and gave him a suspended sentence. After both the prosecution and Macchiarini appealed that ruling, the Svea Court of Appeal heard the case in April and May. Today’s ruling from the five-judge panel is largely a win for the prosecution—it had asked for a 5-year sentence whereas Macchiarini’s lawyer urged the appeals court to acquit him of all charges.

For anyone who does not know the Macchiarini case, it is a ghastly breach of ethics, a horrific travesty betrayal of trust and consent, which left a trail of dead patients and shattered families.  Some may feel that two years is insufficient for the harm, death and treachery he was responsible for.  We have included links to 13 related items.  We don’t necessarily recommend referring to this case in professional development.  In our experience, cases like this can be titillating but they are unlikely to change the attitudes or behaviour of most researchers.

Macchiarini performed experimental surgeries on the three patients in 2011 and 2012 while working at the renowned Karolinska Institute. He implanted synthetic windpipes seeded with stem cells from the patients’ own bone marrow, with the hope the cells would multiply over time and provide an enduring replacement. All three patients died when the implants failed. One patient died suddenly when the implant caused massive bleeding just 4 months after it was implanted; the two others survived for 2.5 and nearly 5 years, respectively, but suffered painful and debilitating complications before their deaths.

In the ruling released today, the appeals judges disagreed with the district court’s decision that the first two patients were treated under “emergency” conditions. Both patients could have survived for a significant length of time without the surgeries, they said. The third case was an “emergency,” the court ruled, but the treatment was still indefensible because by then Macchiarini was well aware of the problems with the technique. (One patient had already died and the other had suffered severe complications.)

The judges ruled that Macchiarini “acted with criminal intent,” even though he hoped the technique would work. They were persuaded by the evidence that he was fully aware “of the risk that the procedures would cause the patients physical injuries and suffering and that he was indifferent to the realization of these risks.” Viveka Lång, one of the appeals judges who heard the case, says Swedish law recognizes three levels of intent, and the court found Macchiarini guilty of the lowest level. Even if it was not his purpose to harm the patients, she says, “was he aware of the potential risk, and did he do [the surgeries] anyway?”

2PNXR73 Stockholm, Sweden. 21st Apr, 2023. The surgeon Paolo Macchiarini at Svea Court of Appeal in Stockholm, Sweden, April 21, 2021 for the fifth day of the trial. The surgeon was previously employed at Karolinska University Hospital where he performed tracheal transplant surgery. Photo: Caisa Rasmussen/TT code 12150 Credit: TT News Agency/Alamy Live News
Transplant surgeon sentenced to prison for failed stem cell treatments
Paolo Macchiarini found guilty of gross assault against three patients on whom he tested synthetic tracheae

Related Reading

(Sweden) Scientists fear further scandals as Macchiarini convicted – Times Higher Education (Ben Upton | June 2022)

(Sweden) Surgeon on trial in Sweden over experimental windpipe transplants – The Guardian (April 2022)

(Sweden) Swedes indict surgeon for stem-cell windpipe transplants – The Washington Post (David Keyton and Jan M. Olsen – AP | September 2020)

Disgraced tracheal transplant surgeon is handed 16 month prison sentence in Italy (Papers: Michael Day | November 2019)

Scandal-weary Swedish government takes over research-fraud investigations – Nature (Holly Else | July 2019)

Learning lessons from the Paolo Macchiarini case – Horizons (Matthias Egger | December 2018)

A Star Surgeon Left a Trail of Dead Patients—and His Whistleblowers Were Punished – LeapsMag (Eve Herold | October 2018)

Disgraced trachea surgeon – and six co-authors – found responsible for misconduct – Science (Alison Abbott | June 2018)

Disgraced surgeon is still publishing on stem cell therapies – Science (Matt Warren | April 2018)

Dropped manslaughter probe of former Karolinska surgeon Macchiarini to be reviewed – The Local SE (December 2017)

Swedish review board finds misconduct by Macchiarini, calls for six retractions – Retraction Watch (Alison McCook | October 2017)

Dr Con Man: the rise and fall of a celebrity scientist who fooled almost everyone – The Guardian (John Rasko and Carl Power | September 2017)

Macchiarini scandal: overstepping the research ethics mark – Euroscientist (Sabine Louët Sepember)

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