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Animal Ethics Biosafety Human Research Ethics Research Integrity

(Australia) Undisclosed industry payments rampant in drug-trial papers – Nature (Clare Watson | March 2022)

Posted by Dr Gary Allen in Human Research Ethics, Research Integrity on April 11, 2022
Keywords: Australia, Clinical trial, Conflicts of interest

The Linked Original Item was Posted On March 24, 2022

A woman covering her own face with her hand, with a dollar sign written on the back.

A quarter of medical researchers involved in clinical trials in Australia did not declare funding from pharmaceutical companies.

One in four Australian medical researchers involved in drug trials failed to declare money they had received from pharmaceutical companies when submitting journal manuscripts, a study reports.

A researcher who fails to disclose or discuss the steps taken to mitigate a conflict of interest is never a good look.  It is especially a concern if someone involved in a clinical trial fails to deal with (at least a perceived) conflict relating to funding from a pharmaceutical company.  This can seriously harm the reputation of individual researchers, potentially their host institution, the publication where their research is reported and potentially clinical research in general.

The authors cross-checked statements on financial conflicts of interest listed by Australian authors of 120 drug trials published in the first eight months of 2020 against a database of company-made payments reported to Medicines Australia, the country’s pharmaceutical-industry association. The research, published in the Journal of General Internal Medicine1 this month, is one of only a few studies outside the United States to examine discrepancies between drug-company payments made to health professionals and author disclosure statements.

The study found that missing or incomplete declarations were common. Half of the trials and a quarter of the 323 Australian authors involved had at least one undeclared financial conflict (see ‘Undeclared conflicts’), with undisclosed payments ranging from AU$140 to AU$97,600 (US$100 to US$71,000) for consulting, advisory meetings, speaker fees and education events.

The results are sobering and similar to those from US studies2, which “suggests that the fundamental problem of conflict-of-interest non-disclosure is a persistent one” in clinical research — evident across journals, across countries and over time, says James Baraldi, a neuroscientist at the University of Pittsburgh, Pennsylvania.

Undisclosed industry payments rampant in drug-trial papers
A quarter of medical researchers involved in clinical trials in Australia did not declare funding from pharmaceutical companies.

Related Reading

Australian Code for the Responsible Conduct of Research, 2018 (NHMRC, et al | June 2018)

Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (Adam Marcus and Ivan Oransky | March 2018)

A Common Standard for Conflict of Interest Disclosure (Guidance: Center for Science in the Public Interest | 2008)

Renowned cancer scientist was paid by chemical firm for 20 years – The Guardian (Sarah Boseley | December 2017)

What should journals do when peer reviewers do not disclose potential conflicts? – Retraction Watch (Victoria Stern | August 2017)

French scientist fined for failure to disclose industry ties – Nature (Barbara Casassus | July 2017)

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